RNA Details
Disease Name
nephritis interstitia
Tissue
kidney
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
RT-PCR;
Target
PTEN
Pathway
PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
Total flavonoids from Smilax glabra Roxb blocks epithelial-mesenchymal transition and inhibits renal interstitial fibrosis by targeting miR-21/PTEN signaling
Year
2019
Function
"Pure total flavonoids from Smilax glabra Roxb (PTFS) has strong anti-diabetic nephropathies and antifibrosis effects both in vitro and in vivo. The mechanism underlying these effects may be related to inhibition of TGF-beta/smad, and their downstream miR-21/PTEN signaling, leading to blocks of diabetic nephropathies process during renal interstitial fibrosis (RIF)."